IGF1R polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IGF1R.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human IGF1R.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SK-BR-3 cell lysate (35 ug/lane) with IGF1R polyclonal antibody (Cat # PAB3055).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with IGF1R polyclonal antibody (Cat # PAB3055) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — IGF1R
Entrez GeneID
3480Protein Accession#
P08069Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
- Barrett Esophagus
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Publication Reference
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The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.
Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ.
PNAS 2004 Feb; 101(7):2076.
Application:IF, IP, WB, Human, MCF-7 cells.
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Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.
Lu Y, Zi X, Zhao Y, Pollak M.
Biochemical and Biophysical Research Communications 2004 Jan; 313(3):709.
Application:IP, WB, Human, MCF-7 cells.
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PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.
Zhao H, Dupont J, Yakar S, Karas M, LeRoith D.
Oncogene 2004 Jan; 23(3):786.
Application:IP, WB, Human, PC-3 cells.
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The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.
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