MAP4K2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human MAP4K2.
Immunogen
Recombinant protein corresponding to human MAP4K2.
Sequence
ETDPLNEPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQRE
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user. Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human lymph node with MAP4K2 polyclonal antibody (Cat # PAB30525) shows strong cytoplasmic positivity in germinal center cells.Immunofluorescence
Immunofluorescent staining of human cell line A-431 with MAP4K2 polyclonal antibody (Cat # PAB30525) shows positivity in vesicles. Antibody staining is shown in green. -
Gene Info — MAP4K2
Entrez GeneID
5871Protein Accession#
Q12851Gene Name
MAP4K2
Gene Alias
BL44, GCK, RAB8IP
Gene Description
mitogen-activated protein kinase kinase kinase kinase 2
Omim ID
603166Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq
Other Designations
B lymphocyte serine/threonine protein kinase|Rab8 interacting protein|germinal centre kinase (GC kinase)
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Interactome
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