Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum with SLITRK1 polyclonal antibody (Cat # PAB30454) shows strong cytoplasmic positivity in Purkinje cells at 1:200-1:500 dilution.
Members of the SLITRK family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM
OTTHUMP00000018546,leucine rich repeat containing 12,slit and trk like 1 protein,slit and trk like gene 1