Western blot analysis of Lane 1: Untreated K562 cell lysates, Lane 2: Synthesized peptide treated K562 cell lysates reacted with BIK (phospho T33) polyclonal antibody (Cat # PAB29645) at 1:500-1:3000 dilution.
Immunohistochemical staining of paraffin-embedded human lung carcinoma tissue reacted with BIK (phospho T33) polyclonal antibody (Cat # PAB29645) at 1:50-1:100 dilution. The picture on the right is treated with the synthesized peptide.
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein-Barr virus in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. [provided by RefSeq