CDC6 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with CDC6 polyclonal antibody (Cat# PAB29498) shows moderate cytoplasmic and nuclear positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of HEK-293 cells with CDC6 polyclonal antibody (Cat# PAB29498) under 1-4 ug/mL working concentration shows positivity in cytoplasm, the Golgi apparatus and nucleus but excluded from the nucleoli. Antibody staining is shown in green.
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Specification
Product Description
CDC6 polyclonal antibody raised against recombinant human CDC6.
Immunogen
Recombinant protein corresponding to amino acids of human CDC6.
Sequence
CQEEVSRPAGKDMMRKLEKHMTAEKGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSHLVLIGIANTLDLTDRILPRLQAREKCKPQLLNFPP
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1-4 ug/mL)
Immunohistochemistry (1:10-1:20)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human stomach with CDC6 polyclonal antibody (Cat# PAB29498) shows moderate cytoplasmic and nuclear positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of HEK-293 cells with CDC6 polyclonal antibody (Cat# PAB29498) under 1-4 ug/mL working concentration shows positivity in cytoplasm, the Golgi apparatus and nucleus but excluded from the nucleoli. Antibody staining is shown in green. -
Gene Info — CDC6
Entrez GeneID
990Protein Accession#
Q99741Gene Name
CDC6
Gene Alias
CDC18L, HsCDC18, HsCDC6
Gene Description
cell division cycle 6 homolog (S. cerevisiae)
Omim ID
602627Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq
Other Designations
CDC18 (cell division cycle 18, S.pombe, homolog)-like|CDC6 cell division cycle 6 homolog|CDC6-related protein|cell division cycle 6 protein
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Interactome
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Pathway
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Disease
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