IPO5 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human skin with IPO5 polyclonal antibody (Cat # PAB29468) shows strong nuclear positivity in epidermal cells.
Immunofluorescence
Immunofluorescent staining of human cell line HeLa with IPO5 polyclonal antibody (Cat # PAB29468) at 1-4 ug/mL concentration shows positivity in nuclear membrane, vesicles and nucleus but excluded from the nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human IPO5.
Immunogen
Recombinant protein corresponding to human IPO5.
Sequence
MPEDQVGKLEATENTISAMA
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:20-1:50)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human skin with IPO5 polyclonal antibody (Cat # PAB29468) shows strong nuclear positivity in epidermal cells.Immunofluorescence
Immunofluorescent staining of human cell line HeLa with IPO5 polyclonal antibody (Cat # PAB29468) at 1-4 ug/mL concentration shows positivity in nuclear membrane, vesicles and nucleus but excluded from the nucleoli. -
Gene Info — IPO5
Entrez GeneID
3843Gene Name
IPO5
Gene Alias
DKFZp686O1576, FLJ43041, IMB3, KPNB3, MGC2068, RANBP5
Gene Description
importin 5
Omim ID
602008Gene Ontology
HyperlinkGene Summary
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq
Other Designations
OTTHUMP00000040733|RAN binding protein 5|Ran_GTP binding protein 5|importin beta-3 subunit|karyopherin (importin) beta 3
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Interactome
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Disease
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