Immunohistochemical staining of human appendix with CDC20 polyclonal antibody (Cat # PAB29462) shows strong cytoplasmic and nuclear positivity in glandular cells.
Immunofluorescent staining of human cell line U-2 OS with CDC20 polyclonal antibody (Cat # PAB29462) at 1-4 ug/mL concentration shows positivity in cytoplasm and nucleus but excluded from the nucleoli.
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq