Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with IGF2R (phospho S2409) polyclonal antibody (Cat# PAB29287) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq