IGF2R (phospho S2409) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human IGF2R.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S2409 of human IGF2R.
Host
Rabbit
Theoretical MW (kDa)
300
Reactivity
Human, Mouse
Specificity
IGF2R (phospho S2409) polyclonal antibody detects endogenous levels of human IGF2R only when phosphorylated at serine 2409.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunohistochemistry (1:50~1:100)
Western Blot (1:500~1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: UV treated COS-7 cells, Lane 2: antigen-specific peptide treated COS-7 cells with IGF2R (phospho S2409) polyclonal antibody (Cat# PAB29287) at 1:500-1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with IGF2R (phospho S2409) polyclonal antibody (Cat# PAB29287) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — IGF2R
Entrez GeneID
3482Protein Accession#
P11717Gene Name
IGF2R
Gene Alias
CD222, CIMPR, M6P-R, MPR1, MPRI
Gene Description
insulin-like growth factor 2 receptor
Omim ID
147280Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq
Other Designations
OTTHUMP00000017536|cation-independent mannose-6 phosphate receptor|insulin-like growth factor-2 receptor (mannose-6-phosphate receptor, cation-independent)
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