Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human brain tissue with GRIN1 (phospho S890) polyclonal antibody (Cat# PAB29269) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
Immunofluorescence staining of methanol-fixed A-549 cells with GRIN1 (phospho S890) polyclonal antibody (Cat# PAB29269) without blocking peptide (A) or preincubated with blocking peptide (B) at 1:100-1:200 dilution.
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq