Western blot analysis of Lane 1: Etoposide treated COS-7 cells, Lane 2: antigen-specific peptide treated COS-7 cells with ARRB1 (phospho S412) polyclonal antibody (Cat# PAB29259) at 1:500-1:1000 dilution.
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer tissue with ARRB1 (phospho S412) polyclonal antibody (Cat# PAB29259) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq