BCAR1 (phospho Y410) polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human BCAR1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y410 of human BCAR1.
Host
Rabbit
Theoretical MW (kDa)
130
Reactivity
Human
Specificity
BCAR1 (phospho Y410) polyclonal antibody detects endogenous levels of human BCAR1 only when phosphorylated at tyrosine 410.
Form
Liquid
Purification
Affinity Chromatography
Recommend Usage
Immunohistochemistry (1:50~1:100)
Western Blot (1:500~1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: antigen-specific peptide treated K562 cells, Lane 2: K562 cells, Lane 3: 3T3 cells with BCAR1 (phospho Y410) polyclonal antibody (Cat# PAB29258) at 1:500-1:1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer tissue with BCAR1 (phospho Y410) polyclonal antibody (Cat# PAB29258) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — BCAR1
Entrez GeneID
9564Protein Accession#
P56945Gene Name
BCAR1
Gene Alias
CAS, CAS1, CASS1, CRKAS, P130Cas
Gene Description
breast cancer anti-estrogen resistance 1
Omim ID
602941Gene Ontology
HyperlinkGene Summary
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM
Other Designations
Cas scaffolding protein family member 1|Crk-associated substrate p130Cas
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