MDC1 (phospho S513) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue by MDC1 (phospho S513) polyclonal antibody (Cat # PAB29247) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S513 of human MDC1.
Host
Rabbit
Theoretical MW (kDa)
226
Reactivity
Human
Specificity
This antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human brain tissue by MDC1 (phospho S513) polyclonal antibody (Cat # PAB29247) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution. -
Gene Info — MDC1
Entrez GeneID
9656Protein Accession#
Q14676Gene Name
MDC1
Gene Alias
DKFZp781A0122, KIAA0170, MGC166888, NFBD1
Gene Description
mediator of DNA damage checkpoint 1
Omim ID
607593Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq
Other Designations
OTTHUMP00000029090|homologue to Drosophila photoreceptor protein calphotin|nuclear factor with BRCT domains 1
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Interactome
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Disease
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