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MDC1 (phospho S513) polyclonal antibody

  • Catalog # : PAB29247
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MDC1.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S513 of human MDC1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 226
  • Reactivity:
  • Human
  • Specificity:
  • This antibody detects endogenous levels of MDC1 only when phosphorylated at serine 513.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Avoid repeated freezing and thawing.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of human brain tissue by MDC1 (phospho S513) polyclonal antibody (Cat # PAB29247) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 9656
  • Gene Name:
  • MDC1
  • Gene Alias:
  • DKFZp781A0122,KIAA0170,MGC166888,NFBD1
  • Gene Description:
  • mediator of DNA damage checkpoint 1
  • Gene Summary:
  • The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000029090,homologue to Drosophila photoreceptor protein calphotin,nuclear factor with BRCT domains 1
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