Immunohistochemical staining of human brain tissue by MDC1 (phospho S513) polyclonal antibody (Cat # PAB29247) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq
OTTHUMP00000029090,homologue to Drosophila photoreceptor protein calphotin,nuclear factor with BRCT domains 1