Immunohistochemical staining of human brain tissue by CTBP1 (phospho S422) polyclonal antibody (Cat # PAB29240) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:50-1:100 dilution.
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq