LINGO1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LINGO1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LINGO1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of LINGO1 (arrow) using rabbit LINGO1 polyclonal antibody (Cat # PAB2857). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the LINGO1 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with LINGO1 polyclonal antibody (Cat # PAB2857) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — LINGO1
Entrez GeneID
84894Protein Accession#
NP_116197;Q96FE5Gene Name
LINGO1
Gene Alias
FLJ14594, LERN1, LRRN6A, MGC17422, UNQ201
Gene Description
leucine rich repeat and Ig domain containing 1
Omim ID
609791Gene Ontology
HyperlinkOther Designations
leucine rich repeat neuronal 6A|leucine-rich repeat neuronal 6A|leucine-rich repeat neuronal protein 1
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Interactome
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Disease
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Publication Reference
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Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O.
PNAS 2007 Sep; 104(36):14430.
Application:IP, WB, Human, Mouse, HEK 293T cells, Mouse brain tissues.
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TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.
Satoh J, Tabunoki H, Yamamura T, Arima K, Konno H.
Neuropathology and Applied Neurobiology 2007 Feb; 33(1):99.
Application:IHC-P, WB-Ti, Human, Multiple sclerosis (MS) brains.
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The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.
Mosyak L, Wood A, Dwyer B, Buddha M, Johnson M, Aulabaugh A, Zhong X, Presman E, Benard S, Kelleher K, Wilhelm J, Stahl ML, Kriz R, Gao Y, Cao Z, Ling HP, Pangalos MN, Walsh FS, Somers WS.
The Journal of Biological Chemistry 2006 Nov; 281(47):36378.
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Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
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