Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human placenta with AMOTL1 polyclonal antibody (Cat # PAB28392) shows strong cytoplasmic and membranous positivity in trophoblastic cells.
Immunofluorescence of A-431 cell line with AMOTL1 polyclonal antibody (Cat # PAB28392) shows positivity in cytoplasm and cell junctions. Fixation/Permeabilization: PFA/Triton X-100
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. [provided by RefSeq