STK11 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK11.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human STK11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of STK11 (arrow) using STK11 polyclonal antibody (Cat # PAB2804).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the STK11 gene (Lane 2).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with STK11 polyclonal antibody (Cat # PAB2804) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — STK11
Entrez GeneID
6794Protein Accession#
NP_000446;Q15831Gene Name
STK11
Gene Alias
LKB1, PJS
Gene Description
serine/threonine kinase 11
Gene Ontology
HyperlinkGene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
polarization-related protein LKB1|serine/threonine protein kinase 11
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Interactome
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Pathway
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Disease
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Publication Reference
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An efficient expression system for the production of functionally active human LKB1.
Martinez-Torrecuadrada JL, Romero S, Nunez A, Alfonso P, Sanchez-Cespedes M, Casal JI.
Journal of Biotechnology 2005 Jan; 115(1):23.
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IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.
Biochemical and Biophysical Research Communications 2004 Nov; 324(3):986.
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.
PNAS 2004 Feb; 101(10):3329.
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An efficient expression system for the production of functionally active human LKB1.
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