STK11 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human STK11.
Immunogen
Recombinant protein corresponding to human STK11.
Sequence
DSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQ
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: negative control (vector only transfected HEK293T cell lysate) and Lane 2: over-expression lysate (co-expressed with a C-terminal myc-DDK tag in mammalian HEK293T cells) with STK11 polyclonal antibody (Cat # PAB31473).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human testis with STK11 polyclonal antibody (Cat # PAB31473) shows moderate cytoplasmic positivity in cells in seminiferous ducts. -
Gene Info — STK11
Entrez GeneID
6794Protein Accession#
Q15831Gene Name
STK11
Gene Alias
LKB1, PJS
Gene Description
serine/threonine kinase 11
Gene Ontology
HyperlinkGene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
polarization-related protein LKB1|serine/threonine protein kinase 11
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Interactome
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Pathway
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Disease
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Publication Reference
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Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.
Co NN, Iglesias D, Celestino J, Kwan SY, Mok SC, Schmandt R, Lu KH.
Cancer 2014 Nov; 120(22):3457.
Application:IHC-P, WB-Ce, WB-Tr, Human, ECC-1, Hec-1A, Hec-1B, Ishikawa, KLE cells, Human endometrial carcinomas.
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Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53.
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