APC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APC.
Immunogen
A synthetic peptide corresponding to human APC.
Host
Rabbit
Theoretical MW (kDa)
310
Reactivity
Human, Mouse, Rat
Specificity
APC polyclonal antibody detects endogenous levels of APC protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of APC polyclonal antibody (Cat # PAB27020) in extracts from COLO 205 cells.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of APC polyclonal antibody (Cat # PAB27020) in paraffin-embedded human lung carcinoma tissue.Enzyme-linked Immunoabsorbent Assay
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Gene Info — APC
Entrez GeneID
324Protein Accession#
P25054Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Interactome
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Pathway
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Disease
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