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PAK1/PAK2/PAK3 polyclonal antibody

  • Catalog # : PAB26728
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PAK1/PAK2/PAK3.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding T423 of human PAK1.
  • Sequence:
  • R-S-Tp-M-V
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity chromatography
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1/PAK2/PAK3 polyclonal antibody (Cat # PAB26728).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5058
  • Protein Accession#:
  • Q13153 (Gene ID : 5058);Q13177 (Gene ID : 5062);O75914 (Gene ID : 5063)
  • Gene Name:
  • PAK1
  • Gene Alias:
  • MGC130000,MGC130001,PAKalpha
  • Gene Description:
  • p21 protein (Cdc42/Rac)-activated kinase 1
  • Gene Summary:
  • PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternativelt spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • STE20 homolog, yeast,p21-activated kinase 1,p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast),p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
  • Gene Information
  • Entrez GeneID:
  • 5062
  • Protein Accession#:
  • Q13153 (Gene ID : 5058);Q13177 (Gene ID : 5062);O75914 (Gene ID : 5063)
  • Gene Name:
  • PAK2
  • Gene Alias:
  • PAK65,PAKgamma
  • Gene Description:
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • Gene Summary:
  • The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq
  • Other Designations:
  • S6/H4 kinase,p21 (CDKN1A)-activated kinase 2,p21-activated kinase 2
  • Gene Information
  • Entrez GeneID:
  • 5063
  • Protein Accession#:
  • Q13153 (Gene ID : 5058);Q13177 (Gene ID : 5062);O75914 (Gene ID : 5063)
  • Gene Name:
  • PAK3
  • Gene Alias:
  • CDKN1A,MRX30,MRX47,OPHN3,PAK3beta,bPAK,hPAK3
  • Gene Description:
  • p21 protein (Cdc42/Rac)-activated kinase 3
  • Gene Summary:
  • PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000023855,OTTHUMP00000062894,beta-PAK,oligophrenin-3,p21 (CDKN1A)-activated kinase 3,p21-activated kinase 3,p21-activated kinase-3,serine/threonine-protein kinase PAK 3
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