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HTR2C polyclonal antibody

  • Catalog # : PAB25545
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of HTR2C.
  • Immunogen:
  • A synthetic peptide corresponding to 20 amino acids at 3rd cytoplasmic domain of human HTR2C.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ANKRD55 (50%).
  • Form:
  • Liquid
  • Purification:
  • Immunoaffinity chromatography
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5.6 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of formalin-fixed, paraffin-embedded human uterus, glandular cells tissue after heat-induced antigen retrieval.
    Using HTR2C polyclonal antibody (Cat # PAB25545).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Entrez GeneID:
  • 3358
  • Gene Name:
  • HTR2C
  • Gene Alias:
  • 5-HT2C,5-HTR2C,HTR1C
  • Gene Description:
  • 5-hydroxytryptamine (serotonin) receptor 2C
  • Gene Summary:
  • Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
  • Other Designations:
  • 5-hydroxytryptamine receptor 2C,OTTHUMP00000023868,OTTHUMP00000023869,serotonin 5-HT-2C receptor,serotonin receptor 2C
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