HTR2C recombinant monoclonal antibody, clone 9H8
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human HTR2C.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human HTR2C.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Hela whole cell lysate; Lane 2: HepG2 whole cell lysate; Lane 3: A549 whole cell lysate.Immunohistochemistry
Immunohistochemistry image of HTR2C recombinant monoclonal antibody, clone 9H8 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HTR2C
Entrez GeneID
3358Protein Accession#
P28335Gene Name
HTR2C
Gene Alias
5-HT2C, 5-HTR2C, HTR1C
Gene Description
5-hydroxytryptamine (serotonin) receptor 2C
Omim ID
312861Gene Ontology
HyperlinkGene Summary
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
Other Designations
5-hydroxytryptamine receptor 2C|OTTHUMP00000023868|OTTHUMP00000023869|serotonin 5-HT-2C receptor|serotonin receptor 2C
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Interactome
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