IRF3 (phospho S385) polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of IRF3.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S385 of IRF3.
Host
Rabbit
Theoretical MW (kDa)
55
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Purity
> 95% by SDS-PAGE
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 293 cells treated with paclitaxel with IRF3 (phospho S385) polyclonal antibody (Cat # PAB25053).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue with IRF3 (phospho S385) polyclonal antibody (Cat # PAB25053). -
Gene Info — IRF3
Entrez GeneID
3661Gene Name
IRF3
Gene Alias
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Gene Description
interferon regulatory factor 3
Omim ID
603734Gene Ontology
HyperlinkGene Summary
IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq
Other Designations
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Interactomes
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Pathways
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Diseases
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Publication Reference
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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.
Aneel R Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D Londino, Joseph S Bednash, Daniela Farkas, Rama K Mallampalli, Mark R Nicolls, John J Ryan, A A Roger Thompson, Stephen Y Chan, Delphine Gomez, Elena A Goncharova, Laszlo Farkas.
iScience 2023 Jan; 26(2):105935.
Application:WB, Human, Human endothelial cells.
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A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.
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