CYP3A4/CYP3A5 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CYP3A4/CYP3A5.
Immunogen
A synthetic peptide corresponding to CYP3A4/CYP3A5.
Host
Rabbit
Theoretical MW (kDa)
57
Reactivity
Human
Specificity
CYP3A4/CYP3A5 polyclonal antibody detects endogenous levels of CYP3A4/CYP3A5 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate with CYP3A4/CYP3A5 polyclonal antibody (Cat # PAB24907).Immunohistochemistry
Immunofluorescence
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Gene Info — CYP3A4
Entrez GeneID
1576Gene Name
CYP3A4
Gene Alias
CP33, CP34, CYP3A, CYP3A3, HLP, MGC126680, NF-25, P450C3, P450PCN1
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 4
Omim ID
124010Gene Ontology
HyperlinkGene Summary
This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq
Other Designations
P450-III, steroid inducible|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450, subfamily IIIA, polypeptide 4|glucocorticoid-inducible P450|nifedipine o
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Gene Info — CYP3A5
Entrez GeneID
1577Gene Name
CYP3A5
Gene Alias
CP35, P450PCN3, PCN3
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 5
Gene Ontology
HyperlinkGene Summary
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. [provided by RefSeq
Other Designations
aryl hydrocarbon hydroxylase|cytochrome P-450|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5|flavoprotein-linked monooxygenase|microsomal monooxygenase|niphedipine oxidase|xenobiotic monooxygenase
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Interactome
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Pathway
- Drug metabolism - cytochrome P450
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Drug metabolism - other enzymes
- gamma-Hexachlorocyclohexane degradation
- gamma-Hexachlorocyclohexane degradation
- Linoleic acid metabolism
- Linoleic acid metabolism
- Metabolic pathways
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Disease
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