CYP3A5 monoclonal antibody, clone F18 P3 B6
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using CYP3A5 monoclonal antibody, clone F18 P3 B6 (Cat # MAB1859) on recombinant CYP3A5 proteins.
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of CYP3A5.
Immunogen
A synthetic peptide corresponding to C-terminus of human CYP3A5.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using CYP3A5 monoclonal antibody, clone F18 P3 B6 (Cat # MAB1859) on recombinant CYP3A5 proteins.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CYP3A5
Entrez GeneID
1577Gene Name
CYP3A5
Gene Alias
CP35, P450PCN3, PCN3
Gene Description
cytochrome P450, family 3, subfamily A, polypeptide 5
Gene Ontology
HyperlinkGene Summary
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. [provided by RefSeq
Other Designations
aryl hydrocarbon hydroxylase|cytochrome P-450|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5|flavoprotein-linked monooxygenase|microsomal monooxygenase|niphedipine oxidase|xenobiotic monooxygenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects.
Kim KA, Park PW, Lee OJ, Kang DK, Park JY.
Journal of Clinical Pharmacology 2007 Jan; 47(1):87.
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Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
Kumarakulasingham M, Rooney PH, Dundas SR, Telfer C, Melvin WT, Curran S, Murray GI.
Clinical Cancer Research 2005 May; 11(10):3758.
Application：IHC, WB-Ti, Human, Human colorectal cancer.
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Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation.
McCune JS, Risler LJ, Phillips BR, Thummel KE, Blough D, Shen DD.
Drug Metabolism and Disposition 2005 Jul; 33(7):1074.
Application：WB-Ti, Human, Liver.
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Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects.
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