Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human testis with FGD4 polyclonal antibody (Cat # PAB23406) shows distinct cytoplasmic positivity in cells in seminiferus ducts.

Immunofluorescence

Immunofluorescent staining of human cell line U-2 OS with FGD4 polyclonal antibody (Cat # PAB23406) at 1-4 ug/mL dilution shows positivity in cytoskeleton (actin filaments).

Entrez GeneID

121512

Protein Accession#

Q96M96

Gene Name

FGD4

Gene Alias

CMT4H, DKFZp313E1818, DKFZp434K1572, FLJ34370, FLJ42663, FRABP, MGC57222, ZFYVE6

Gene Description

FYVE, RhoGEF and PH domain containing 4

Omim ID

609311 611104

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq

Other Designations

FGD1 family, member 4|FGD1-related F-actin-binding protein|actin-filament binding protein frabin|zinc finger FYVE domain-containing protein 6