HDAC4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HDAC4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human HDAC4.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The HDAC4 polyclonal antibody (Cat # PAB2329) is used in Western blot to detect HDAC4 in mouse brain tissue lysate. -
Gene Info — HDAC4
Entrez GeneID
9759Protein Accession#
P56524Gene Name
HDAC4
Gene Alias
HA6116, HD4, HDAC-A, HDACA, KIAA0288
Gene Description
histone deacetylase 4
Omim ID
605314Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq
Other Designations
histone deacetylase A
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Interactome
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Disease
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Publication Reference
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Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
Chan JK, Sun L, Yang XJ, Zhu G, Wu Z.
The Journal of Biological Chemistry 2003 Jun; 278(26):23515.
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Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response.
Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ.
International Journal of Cell Biology 2003 Mar; 160(7):1017.
Application:IF, IP, WB, Human, HeLa cells.
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Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.
Zhang CL, McKinsey TA, Olson EN.
Molecular and Cellular Biology 2002 Oct; 22(20):7302.
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Functional characterization of an amino-terminal region of HDAC4 that possesses MEF2 binding and transcriptional repressive activity.
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