PIAS4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIAS4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PIAS4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PIAS4 polyclonal antibody (Cat # PAB2258) is used in Western blot to detect recombinant GST-PIAS4 in bacterial cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the PIAS4 polyclonal antibody (Cat # PAB2258) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — PIAS4
Entrez GeneID
51588Protein Accession#
NP_056981;Q8N2W9Gene Name
PIAS4
Gene Alias
FLJ12419, MGC35296, PIASY, Piasg, ZMIZ6
Gene Description
protein inhibitor of activated STAT, 4
Omim ID
605989Gene Ontology
HyperlinkGene Summary
O
Other Designations
protein inhibitor of activated STAT protein PIASy|zinc finger, MIZ-type containing 6
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Interactome
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Pathway
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Publication Reference
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Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.
Imoto S, Sugiyama K, Muromoto R, Sato N, Yamamoto T, Matsuda T.
The Journal of Biological Chemistry 2003 Sep; 278(36):34253.
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Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy.
Chun TH, Itoh H, Subramanian L, Iniguez-Lluhi JA, Nakao K.
Circulation Research 2003 Jun; 92(11):1201.
Application:IP, WB, Human, Rat, HEK 293, Rat-2 cells.
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A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.
Subramanian L, Benson MD, Iniguez-Lluhi JA.
The Journal of Biological Chemistry 2003 Mar; 278(11):9134.
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Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3.
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