NEU2 polyclonal antibody
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis of recombinant protein with NEU2 polyclonal antibody (Cat # PAB19939) at 1:500 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NEU2.
Immunogen
A synthetic peptide corresponding to amino acids 110-124 of human NEU2.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with human Neu2. Based on sequence we expect this antibody to react with neuraminidase from other sources, although specific reactivity has not been confirmed. Cross-reactivity against Neu1 has not yet been established. Neuraminidases are highly conserved in mammals and therefore cross reactivity is expected with mouse and rat Neu2.
Form
Liquid
Purification
Immunoaffinity purification
Recommend Usage
ELISA (1:10000-1:50000)
Western Blot (1:500- 1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis of recombinant protein with NEU2 polyclonal antibody (Cat # PAB19939) at 1:500 dilution.Immunocytochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NEU2
Entrez GeneID
4759Gene Name
NEU2
Gene Alias
MGC129579, SIAL2
Gene Description
sialidase 2 (cytosolic sialidase)
Omim ID
605528Gene Ontology
HyperlinkGene Summary
This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq
Other Designations
N-acetyl-alpha-neuraminidase 2|OTTHUMP00000164374|cytosolic sialidase|neuraminidase 2|sialidase 2
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Interactome
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Pathway
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Publication Reference
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Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.
Nath S, Mandal C, Chatterjee U, Mandal C.
Cell Death & Disease 2018 Feb; 9(2):210.
Application：IHC-P, WB-Tr, Human, AsPC1, MIAPaCa2 cells, Human pancreatic cancer.
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Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells.
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