CNR1 (isoform A) polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CNR1.
Immunogen
A synthetic peptide corresponding to N-terminus of human CNR1.
Sequence
SNDIQYEDIKGDMAS-C
Host
Goat
Theoretical MW (kDa)
52.9, 52.8
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize reported isoform a (NP_057167.2) only. Reported variants represent identical protein: NP_001153731.1, NP_001153732.1, NP_057167.2, NP_001153730.1, NP_001153698.1.
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
CNR1 (isoform A) polyclonal antibody (Cat # PAB19644) (1 ug/mL) staining of NIH/3T3 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CNR1
Entrez GeneID
1268Protein Accession#
NP_057167.2Gene Name
CNR1
Gene Alias
CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR
Gene Description
cannabinoid receptor 1 (brain)
Omim ID
114610Gene Ontology
HyperlinkGene Summary
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000016838|OTTHUMP00000016839|OTTHUMP00000016840|central cannabinoid receptor
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Interactome
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Disease
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