Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with UBE4B polyclonal antibody (Cat # PAB1930), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000001726,OTTHUMP00000001727,homologous to yeast UFD2,homozygously deleted in neuroblastoma-1,ubiquitin-fusion degradation protein 2,ubiquitination factor E4B,ubiquitination factor E4B (homologous to yeast UFD2)