Products

Western Blot (Tissue lysate)

The UBE4B polyclonal antibody (Cat # PAB1930) is used in Western blot to detect UBE4B in mouse kidney tissue lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with UBE4B polyclonal antibody (Cat # PAB1930), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Entrez GeneID

10277

Protein Accession#

NP_006039;O95155

Gene Name

UBE4B

Gene Alias

E4, HDNB1, KIAA0684, UBOX3, UFD2

Gene Description

ubiquitination factor E4B (UFD2 homolog, yeast)

Gene Ontology

Hyperlink

Gene Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000001726|OTTHUMP00000001727|homologous to yeast UFD2|homozygously deleted in neuroblastoma-1|ubiquitin-fusion degradation protein 2|ubiquitination factor E4B|ubiquitination factor E4B (homologous to yeast UFD2)