SFRP1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SFRP1.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of humanSFRP1.
Sequence
KNHECPTFQSVFK
Host
Goat
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:1000)
Immunohistochemistry (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SFRP1 polyclonal antibody (Cat # PAB19007, 3.8 ug/mL) staining of paraffin embedded human kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SFRP1
Entrez GeneID
6422Protein Accession#
NP_003003.3Gene Name
SFRP1
Gene Alias
FRP, FRP-1, FRP1, FrzA, SARP2
Gene Description
secreted frizzled-related protein 1
Omim ID
604156Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq
Other Designations
secreted apoptosis-related protein 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Tear levels of SFRP1 are significantly reduced in keratoconus patients.
You J, Hodge C, Wen L, McAvoy JW, Madigan MC, Sutton G.
Molecular Vision 2013 Feb; 19:509.
Application:ELISA, Human, Human tear.
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Tear levels of SFRP1 are significantly reduced in keratoconus patients.
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