NFATC2 polyclonal antibody
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Specifications
Product Description
Goat polyclonal antibody raised against synthetic peptide of NFATC2.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human NFATC2.
Sequence
C-QQFRTGLSSPDARYQ
Host
Goat
Theoretical MW (kDa)
110
Reactivity
Human
Specificity
This antibody is expected to recognize all three reported isoforms (NP_036472.2; NP_775114.1; NP_001129493.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
NFATC2 polyclonal antibody (Cat # PAB18714) (0.3 ug/mL) staining of Molt 4 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
NFATC2 polyclonal antibody (Cat # PAB18714)(3.8 ug/mL) staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NFATC2
Entrez GeneID
4773Protein Accession#
NP_036472.2;NP_775114.1;NP_001129493.1Gene Name
NFATC2
Gene Alias
KIAA0611, NFAT1, NFATP
Gene Description
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Omim ID
600490Gene Ontology
HyperlinkGene Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
NFAT pre-existing subunit|NFAT transcription complex, preexisting component|OTTHUMP00000031291|T cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting component|preexisting nucl
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Interactomes
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Pathways
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Diseases
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