STMN1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STMN1.
Immunogen
A synthetic peptide corresponding to residues surrounding S15 of human STMN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to STMN1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells, using STMN1 polyclonal antibody (Cat # PAB18501).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human thymus gland tissue using STMN1 polyclonal antibody (Cat # PAB18501).
Peptide "+" means "peptide blocking".Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — STMN1
Entrez GeneID
3925Protein Accession#
P16949Gene Name
STMN1
Gene Alias
LAP18, Lag, OP18, PP17, PP19, PR22, SMN
Gene Description
stathmin 1/oncoprotein 18
Omim ID
151442Gene Ontology
HyperlinkGene Summary
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000008527|OTTHUMP00000008528|OTTHUMP00000008530|leukemia-associated phosphoprotein p18|metablastin|oncoprotein 18|phosphoprotein 19|prosolin|stathmin 1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW.
The Journal of Cell Biology 2005 Apr; 169(2):331.
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Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.
Essafi A, Fernandez de Mattos S, Hassen YA, Soeiro I, Mufti GJ, Thomas NS, Medema RH, Lam EW.
Oncogene 2005 Mar; 24(14):2317.
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME.
Molecular and Cellular Biology 2001 Feb; 21(3):952.
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Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
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