SNCA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SNCA.
Immunogen
A synthetic peptide corresponding to residues surrounding S129 of human SNCA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to SNCA.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HUVEC cells, using SNCA polyclonal antibody (Cat # PAB18226).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SNCA polyclonal antibody (Cat # PAB18226).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — SNCA
Entrez GeneID
6622Protein Accession#
P37840Gene Name
SNCA
Gene Alias
MGC110988, NACP, PARK1, PARK4, PD1
Gene Description
synuclein, alpha (non A4 component of amyloid precursor)
Gene Ontology
HyperlinkGene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161559|OTTHUMP00000161561|alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid
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Interactome
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Disease
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Publication Reference
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Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene.
Ninkina N, Papachroni K, Robertson DC, Schmidt O, Delaney L, O'Neill F, Court F, Rosenthal A, Fleetwood-Walker SM, Davies AM, Buchman VL.
Molecular and Cellular Biology 2003 Nov; 23(22):8233.
Application:NB, Mouse, Neurons.
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Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease.
Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Bjorklund A.
PNAS 2003 Mar; 100(5):2884.
Application:IHC, Monkey, Brains.
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Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.
Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, Brundin P.
The Journal of Biological Chemistry 2002 Oct; 277(41):38884.
Application:WB-Ce, WB-Tr, Human, MESC2.10 cells.
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Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene.
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