ESR1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ESR1.
Immunogen
A synthetic peptide corresponding to human ESR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ESR1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293cells, using ESR1 polyclonal antibody (Cat # PAB18170).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using ESR1 polyclonal antibody (Cat # PAB18170).
Peptide "+" means "peptide blocking".Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ESR1
Entrez GeneID
2099Protein Accession#
P03372Gene Name
ESR1
Gene Alias
DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
Gene Description
estrogen receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq
Other Designations
OTTHUMP00000017718|OTTHUMP00000017719|estrogen receptor alpha
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Interactomes
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Diseases
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Publication Reference
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The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study.
Ahmed S, Othman NH.
Amino Acids 2017 Apr; 17(1):208.
Application:IHC-P, Human, Human breast cancer.
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Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model.
Ahmed S, Sulaiman SA, Othman NH.
Evidence-Based Complementary and Alternative Medicine : ECAM. 2017 Apr; 2017:5904361.
Application:IHC, Human, Rat, Human colon cancer, Rat breast tissue.
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Estrogen receptor-alpha expression in osmosensitive elements of the lamina terminalis: regulation by hypertonicity.
Somponpun SJ, Johnson AK, Beltz T, Sladek CD.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2004 Sep; 287(3):R661.
Application:ELISA, ICC, IF, Rat, Rat lamina terminalis.
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Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge.
Temel S, Lin W, Lakhlani S, Jennes L.
Endocrinology 2002 Oct; 143(10):3974.
Application:IHC-P, Rat, Brain.
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The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study.
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