MAPKAPK2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells, treated with Ca2+ (40 nM, 30 mins), using MAPKAPK2 polyclonal antibody (Cat # PAB18100).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MAPKAPK2 polyclonal antibody (Cat # PAB18100).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAPKAPK2.
Immunogen
A synthetic peptide corresponding to human MAPKAPK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to MAPKAPK2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells, treated with Ca2+ (40 nM, 30 mins), using MAPKAPK2 polyclonal antibody (Cat # PAB18100).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MAPKAPK2 polyclonal antibody (Cat # PAB18100).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAPKAPK2
Entrez GeneID
9261Protein Accession#
P49137Gene Name
MAPKAPK2
Gene Alias
MK2
Gene Description
mitogen-activated protein kinase-activated protein kinase 2
Omim ID
602006Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000034531|OTTHUMP00000034532
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Interactome
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Pathway
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Publication Reference
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ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells.
Miguel SM, Namdar-Attar M, Noh T, Frenkel B, Bab I.
The Journal of Biological Chemistry 2005 Nov; 280(45):37495.
Application：WB, Mouse, MC3T3 E1 cells.
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Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart: evidence for involvement of p38 MAPK.
Nakano A, Baines CP, Kim SO, Pelech SL, Downey JM, Cohen MV, Critz SD.
Circulation Research 2000 Feb; 86(2):144.
Application：WB-Ti, Rabbit, Heart.
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ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells.
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