Products

Western Blot (Tissue lysate)

The UBA3 polyclonal antibody (Cat # PAB1774) is used in Western blot to detect UBA3 in mouse brain tissue lysate.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with UBA3 polyclonal antibody (Cat # PAB1774) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

9039

Protein Accession#

NP_003959;Q8TBC4

Gene Name

UBA3

Gene Alias

DKFZp566J164, MGC22384, UBE1C, hUBA3

Gene Description

ubiquitin-like modifier activating enzyme 3

Omim ID

603172

Gene Ontology

Hyperlink

Gene Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq

Other Designations

Nedd8-activating enzyme hUba3|UBA3, ubiquitin-activating enzyme E1 homolog|ubiquitin-activating enzyme 3|ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)|ubiquitin-activating enzyme E1C (homologous to yeast UBA3)