MAPK8IP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of extracts from mouse brain cells, using MAPK8IP2 polyclonal antibody (Cat # PAB17382).
Peptide "+" means "with peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MAPK8IP2 polyclonal antibody (Cat # PAB17382).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAPK8IP2.
Immunogen
A synthetic peptide corresponding to internal of human MAPK8IP2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total MAPK8IP2 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (150mM NaCl, 0.02% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of extracts from mouse brain cells, using MAPK8IP2 polyclonal antibody (Cat # PAB17382).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MAPK8IP2 polyclonal antibody (Cat # PAB17382).
Peptide "+" means "with peptide blocking". -
Gene Info — MAPK8IP2
Entrez GeneID
23542Protein Accession#
Q13387Gene Name
MAPK8IP2
Gene Alias
IB2, JIP2, PRKM8IPL
Gene Description
mitogen-activated protein kinase 8 interacting protein 2
Omim ID
607755Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq
Other Designations
JNK MAP kinase scaffold protein JIP2|JNK-interacting protein 2|PRKM8 interacting protein-like|homologous to mouse JIP-1|islet-brain 2
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Interactome
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Pathway
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Publication Reference
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cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.
Negri S, Oberson A, Steinmann M, Sauser C, Nicod P, Waeber G, Schorderet DF, Bonny C.
Genomics 2000 Mar; 64(3):324.
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The DNA sequence of human chromosome 22.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al..
Nature 1999 Dec; 402(6761):489.
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The JIP group of mitogen-activated protein kinase scaffold proteins.
Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ.
Molecular and Cellular Biology 1999 Oct; 19(10):7245.
Application：IF, IP, WB-Ce, WB-Tr, Monkey, Rat, COS-7, Rin5F cells.
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cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.
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