TREX1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 polyclonal antibody (Cat # PAB16681) at (A) 0.5 ug/mL and (B) 1 ug/mL .
Immunohistochemistry
Immunohistochemistry of TREX1 in human spleen tissue with TREX1 polyclonal antibody (Cat # PAB16681) at 2.5 ug/mL .
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TREX1.
Immunogen
A synthetic peptide corresponding to internal region 15 amino acids of human TREX1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of TREX1 in human spleen tissue lysate with TREX1 polyclonal antibody (Cat # PAB16681) at (A) 0.5 ug/mL and (B) 1 ug/mL .Immunohistochemistry
Immunohistochemistry of TREX1 in human spleen tissue with TREX1 polyclonal antibody (Cat # PAB16681) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
-
Gene Info — TREX1
Entrez GeneID
11277Protein Accession#
NP_057465Gene Name
TREX1
Gene Alias
AGS1, AGS5, CRV, DKFZp434J0310, DRN3, HERNS
Gene Description
three prime repair exonuclease 1
Gene Ontology
HyperlinkGene Summary
This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
3' repair exonuclease 1|OTTHUMP00000164813|deoxyribonuclease III, dnaQ/mutD-like
-
Interactome
-
Disease
-
Publication Reference
-
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J; ARUK Consortium, Blumenau S, Thielke M, Josties C, Freyer D, Dietrich A, Hammer M, Baier M, Dirnagl U, Morgan K, Powell JF, Kauwe JS, Cruchaga C, Goate AM, Singleton AB, Guerreiro R, Hodges A, Hardy J.
Neurobiology of Aging 2018 Jun; 66:179.e17.
Application：IHC, Mouse, Cortex.
-
Trex1 prevents cell-intrinsic initiation of autoimmunity.
Stetson DB, Ko JS, Heidmann T, Medzhitov R.
Cell 2008 Aug; 134(4):587.
Application：WB-Tr, Mouse, Mouse marrow-derived macrophages.
-
ATR and ATRIP: partners in checkpoint signaling.
Cortez D, Guntuku S, Qin J, Elledge SJ.
Science 2001 Nov; 294(5547):1713.
-
Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes.
Mazur DJ, Perrino FW.
The Journal of Biological Chemistry 2001 May; 276(18):14718.
-
Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com