TLN1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
TLN1 polyclonal antibody (Cat # PAB16640) (1 ug/mL) staining of human peripheral mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TLN1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human TLN1.
Sequence
C-QEALHTQMLTAVQE
Host
Goat
Theoretical MW (kDa)
270
Reactivity
Human
Specificity
This antibody is not expected to cross-react with the highly similar protein Talin 2.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
TLN1 polyclonal antibody (Cat # PAB16640) (1 ug/mL) staining of human peripheral mononucleocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TLN1
Entrez GeneID
7094Protein Accession#
NP_006280.3Gene Name
TLN1
Gene Alias
ILWEQ, KIAA1027, TLN
Gene Description
talin 1
Omim ID
186745Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Publication Reference
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Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.
Manevich E, Grabovsky V, Feigelson SW, Alon R.
The Journal of Biological Chemistry 2007 Aug; 282(35):25338.
Application：WB-Tr, Human, Jurkat cells.
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Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1.
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