OTUD5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OTUD5.
Immunogen
A synthetic peptide corresponding to C-terminus 13 amino acids of human OTUD5.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of OTUD5 in human kidney lysate with OTUD5 polyclonal antibody (Cat # PAB16553) at (Lane 1) 1 and (Lane 2) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of OTUD5 in mouse kidney tissue with OTUD5 polyclonal antibody (Cat # PAB16553) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — OTUD5
Entrez GeneID
55593Protein Accession#
EAW50723Gene Name
OTUD5
Gene Alias
DKFZp761A052, DUBA, MGC104871
Gene Description
OTU domain containing 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000025821|deubiquinating enzyme A
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Interactome
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Publication Reference
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DUBA: a deubiquitinase that regulates type I interferon production.
Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM.
Science 2007 Dec; 318(5856):1628.
Application:IP, WB-Tr, Human, Mouse, HEK 293 cells, BMDMs, RAW264.3 cells.
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Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family.
Borodovsky A, Ovaa H, Kolli N, Gan-Erdene T, Wilkinson KD, Ploegh HL, Kessler BM.
Chemistry & Biology 2002 Oct; 9(10):1149.
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DUBA: a deubiquitinase that regulates type I interferon production.
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