OTUD5 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum using OTUD5 polyclonal antibody (Cat # PAB30519) shows cytoplasmic positivity in glandular cells.
Immunofluorescence
Immunofluorescent staining of U-2 OS cells using OTUD5 polyclonal antibody (Cat # PAB30519) shows positivity in cytoplasm (green).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human OTUD5.
Immunogen
Recombinant protein corresponding to amino acids 439 - 555 of human OTUD5.
Sequence
AAASSGLEEWTSRSPRQRSSASSPEHPELHAELGMKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLD
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1 - 4 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200 - 1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human rectum using OTUD5 polyclonal antibody (Cat # PAB30519) shows cytoplasmic positivity in glandular cells.Immunofluorescence
Immunofluorescent staining of U-2 OS cells using OTUD5 polyclonal antibody (Cat # PAB30519) shows positivity in cytoplasm (green). -
Gene Info — OTUD5
Entrez GeneID
55593Protein Accession#
Q96G74Gene Name
OTUD5
Gene Alias
DKFZp761A052, DUBA, MGC104871
Gene Description
OTU domain containing 5
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000025821|deubiquinating enzyme A
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