NFKB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NFKB2.
Immunogen
A synthetic peptide corresponding to C-terminus of human NFKB2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NFKB2
Entrez GeneID
4791Gene Name
NFKB2
Gene Alias
LYT-10, LYT10
Gene Description
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Omim ID
164012Gene Ontology
HyperlinkGene Summary
NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528].[supplied by OMIM
Other Designations
OTTHUMP00000020371|OTTHUMP00000059136|nuclear factor of kappa light chain gene enhancer in B-cells 2|nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
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Interactome
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Pathway
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Disease
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Publication Reference
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The generation of nfkb2 p52: mechanism and efficiency.
Heusch M, Lin L, Geleziunas R, Greene WC.
Oncognen 1999 Nov; 18(46):6201.
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A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.
Li Z, Nabel GJ.
Molecular and Cellular Biology 1997 Oct; 17(10):6184.
Application:IP, Human, HEK 293 cells, Recombinant protein.
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Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.
Dobrzanski P, Ryseck RP, Bravo R.
The EMBO Journal 1994 Oct; 13(19):4608.
Application:WB-Tr, Monkey, COS cells.
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The generation of nfkb2 p52: mechanism and efficiency.
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