SEPT6 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
SEPT6 polyclonal antibody (Cat # PAB14390) (1 μg/mL) staining of Human Testis (A), (0.1 μg/mL) Duodenum (B), (0.5 μg/mL) Kidney (C) and (0.3 μg/mL) Tonsil (D) lysate (35 μg protein in RIPA buffer). Detected by chemiluminescence.
Western Blot (Cell lysate)
SEPT6 polyclonal antibody (Cat # PAB14390) (0.1 μg/mL) staining of Daudi (A), Jurkat (B) and MOLT4 (C) cell lysate (35 μg protein in RIPA buffer). Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil with SEPT6 polyclonal antibody (Cat # PAB14390) (3.8 ug/mL). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SEPT6.
Immunogen
A synthetic peptide corresponding to human SEPT6.
Sequence
C-DEVNAFKQRKTA
Host
Goat
Theoretical MW (kDa)
48.9, 49.7, 49.2
Reactivity
Human
Specificity
Approx 50 KDa band observed in human testis, thyroid gland and MOLT 4 cell lysates (calculated MW of 49.7 KDa according to NP_055944.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Immunohistochemistry (3-5 μg/mL)
Western Blot (0.1-1 μg/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SEPT6 polyclonal antibody (Cat # PAB14390) (1 μg/mL) staining of Human Testis (A), (0.1 μg/mL) Duodenum (B), (0.5 μg/mL) Kidney (C) and (0.3 μg/mL) Tonsil (D) lysate (35 μg protein in RIPA buffer). Detected by chemiluminescence.Western Blot (Cell lysate)
SEPT6 polyclonal antibody (Cat # PAB14390) (0.1 μg/mL) staining of Daudi (A), Jurkat (B) and MOLT4 (C) cell lysate (35 μg protein in RIPA buffer). Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human tonsil with SEPT6 polyclonal antibody (Cat # PAB14390) (3.8 ug/mL). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SEPT6
Entrez GeneID
23157Protein Accession#
NP_665798.1;NP_055944.2;NP_665801.1Gene Name
SEPT6
Gene Alias
KIAA0128, MGC16619, MGC20339, SEP2, SEPT2
Gene Description
septin 6
Omim ID
300683Gene Ontology
HyperlinkGene Summary
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000023916|OTTHUMP00000023918|OTTHUMP00000023921|septin 2
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Interactome
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Publication Reference
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Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
Kremer BE, Adang LA, Macara IG.
Cell 2007 Sep; 130(5):837.
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Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
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