CDK10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
CDK10 polyclonal antibody (Cat # PAB13668) (0.5 ug/mL) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CDK10.
Immunogen
A synthetic peptide corresponding to human CDK10.
Sequence
AEPDLECEQIRLK
Host
Goat
Theoretical MW (kDa)
41
Reactivity
Human
Specificity
Approximately 37 KDa band observed in human lung lysates and in lysates of cell lines HEK293, A-549 and HepG2 (calculated MW of 41.0 KDa according to NP_443714.3).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
CDK10 polyclonal antibody (Cat # PAB13668) (0.5 ug/mL) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDK10
Entrez GeneID
8558Protein Accession#
NP_443714.3Gene Name
CDK10
Gene Alias
PISSLRE
Gene Description
cyclin-dependent kinase 10
Omim ID
603464Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CDC2-related protein kinase|cell division protein kinase 10|cyclin-dependent kinase (CDC2-like) 10|cyclin-dependent kinase related protein|serine/threonine protein kinase PISSLRE
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Interactome
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Publication Reference
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Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
Iorns E, Turner NC, Elliott R, Syed N, Garrone O, Gasco M, Tutt AN, Crook T, Lord CJ, Ashworth A.
Cancer Cell 2008 Feb; 13(2):91.
Application：WB-Tr, Human, MCF-7 cells.
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Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
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