Rabbit polyclonal antibody raised against synthetic peptide of PTGS1.
A synthetic peptide corresponding to PTGS1.
Human, Rat, Sheep
The polyclonal antibody with the highest specificity for Prostaglandin H Synthase 1 (PGHS-1), also known as Cyclooxygenase 1 (COX-1) and corresponds to a sequence region unique to COX-1. This antibody reacts with native, as well as, recombinant COX-1 from several species including human, sheep, rat and most other mammalian species, except mouse. It does not cross-react with COX-2 from any of the species examined to date.
Western Blot (1:1000) The optimal working dilution should be determined by the end user.
In buffer containing 0.01% sodium azide
Store at -20°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
OTTHUMP00000022052,OTTHUMP00000022053,prostaglandin G/H synthase and cyclooxygenase,prostaglandin-endoperoxide synthase 1