PTGS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTGS1.
Immunogen
A synthetic peptide corresponding to PTGS1.
Host
Rabbit
Reactivity
Human, Rat, Sheep
Specificity
The polyclonal antibody with the highest specificity for Prostaglandin H Synthase 1 (PGHS-1), also known as Cyclooxygenase 1 (COX-1) and corresponds to a sequence region unique to COX-1. This antibody reacts with native, as well as, recombinant COX-1 from several species including human, sheep, rat and most other mammalian species, except mouse. It does not cross-react with COX-2 from any of the species examined to date.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.01% sodium azide
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — PTGS1
Entrez GeneID
5742Gene Name
PTGS1
Gene Alias
COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Gene Description
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Omim ID
176805Gene Ontology
HyperlinkGene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
Other Designations
OTTHUMP00000022052|OTTHUMP00000022053|prostaglandin G/H synthase and cyclooxygenase|prostaglandin-endoperoxide synthase 1
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Interactome
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Pathway
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Disease
- Abdominal Pain
- Adenocarcinoma
- Adenoma
- Adenomatous Polyps
- Alzheimer disease
- Asthma
- Atherosclerosis
- Atrophy
- Brain Ischemia
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Publication Reference
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Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals.
Parfenova H, Eidson TH, Leffler CW.
The American Journal of Physiology 1997 Jul; 273(1 Pt 1):C277.
Application:IF, WB-Ti, Pig, Liver, Kidney, Cerebral cortex, Lung, Spleen, Cerebral microvessels, Pulmonary microvessels, Aortic endothelium.
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The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
Otto JC, Smith WL.
The Journal of Biological Chemistry 1994 Aug; 269(31):19868.
Application:WB-Ti, WB-Tr, Sheep, Monkey, Seminal vesicles, COS-1 cells.
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Upregulation of COX-2 in cerebral microvascular endothelial cells by smooth muscle cell signals.
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