PTGS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human PTGS1.
Immunogen
Recombinant protein corresponding to human PTGS1.
Sequence
MPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: Human cell line RT-4, Lane 2: Human cell line U-251MG sp, Lane 3: Human cell line A-431, Lane 4: Human liver tissue, Lane 5: Human tonsil tissue with PTGS1 polyclonal antibody (Cat # PAB29525) at 1:100-1:250 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human hippocampus with PTGS1 polyclonal antibody (Cat # PAB29525) shows strong cytoplasmic positivity in neuronal cells at 1:50-1:200 dilution. -
Gene Info — PTGS1
Entrez GeneID
5742Gene Name
PTGS1
Gene Alias
COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS
Gene Description
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Omim ID
176805Gene Ontology
HyperlinkGene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq
Other Designations
OTTHUMP00000022052|OTTHUMP00000022053|prostaglandin G/H synthase and cyclooxygenase|prostaglandin-endoperoxide synthase 1
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Interactome
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Pathway
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Disease
- Abdominal Pain
- Adenocarcinoma
- Adenoma
- Adenomatous Polyps
- Alzheimer disease
- Asthma
- Atherosclerosis
- Atrophy
- Brain Ischemia
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