DISC1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DISC1.
Immunogen
A synthetic peptide corresponding to internal region 18 amino acids of human DISC1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DISC1 in SK-N-SH cell lysate with DISC1 polyclonal antibody (Cat # PAB13288) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of DISC1 in HeLa cells with DISC1 polyclonal antibody (Cat # PAB13288) at 5 ug/mL . -
Gene Info — DISC1
Entrez GeneID
27185Protein Accession#
NP_061132Gene Name
DISC1
Gene Alias
C1orf136, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, SCZD9
Gene Description
disrupted in schizophrenia 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000035959|OTTHUMP00000035960
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Interactome
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Disease
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Publication Reference
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Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
Duan X, Chang JH, Ge S, Faulkner RL, Kim JY, Kitabatake Y, Liu XB, Yang CH, Jordan JD, Ma DK, Liu CY, Ganesan S, Cheng HJ, Ming GL, Lu B, Song H.
Cell 2007 Sep; 130(6):1146.
Application:IS, Mouse, Coronal brain.
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DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Jill A Morris, Geeta Kandpal, Lei Ma, Christopher P Austin.
Human Molecular Genetics 2003 Jul; 12(13):1591.
Application:IF, WB-Tr, Human, HEK 293 cells, Human NT2N neurons.
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Disruption of two novel genes by a translocation co-segregating with schizophrenia.
Millar JK, Wilson-Annan JC, Anderson S, Christie S, Taylor MS, Semple CA, Devon RS, St Clair DM, Muir WJ, Blackwood DH, Porteous DJ.
Human Molecular Genetics 2000 May; 9(9):1415.
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Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain.
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