DISC1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DISC1.
Immunogen
A synthetic peptide corresponding to human DISC1.
Sequence
C-HSEDKRKTPLKVLE
Host
Goat
Theoretical MW (kDa)
93.6, 91.1
Reactivity
Human
Specificity
This antibody is expected to recognize isoforms L ( NP_061132.2) and Lv (NP_001012975.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DISC1 polyclonal antibody (Cat # PAB7079) (0.1 ug/mL) staining of human brain (hippocampus) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DISC1
Entrez GeneID
27185Protein Accession#
NP_001012975.1;NP_061132.2Gene Name
DISC1
Gene Alias
C1orf136, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, SCZD9
Gene Description
disrupted in schizophrenia 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000035959|OTTHUMP00000035960
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Interactome
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Disease
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Publication Reference
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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Millar JK, Pickard BS, Mackie S, James R, Christie S, Buchanan SR, Malloy MP, Chubb JE, Huston E, Baillie GS, Thomson PA, Hill EV, Brandon NJ, Rain JC, Camargo LM, Whiting PJ, Houslay MD, Blackwood DH, Muir WJ, Porteous DJ.
Science 2005 Nov; 310(5751):1187.
Application:IF, WB-Ce, Human, Lymphoblastoid, SH-SY5Y, Hippocampal primary cells.
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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
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