BUB1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BUB1.
Immunogen
A synthetic peptide corresponding to N-terminus 19 amino acids of human BUB1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of BUB1 in A-20 lysate with BUB1 polyclonal antibody (Cat # PAB13270) at (A) 2 and (B) 4 ug/mL .Immunocytochemistry
Immunocytochemistry of BUB1 in A-20 cells with BUB1 polyclonal antibody (Cat # PAB13270) at 10 ug/mL . -
Gene Info — BUB1
Entrez GeneID
699Protein Accession#
O43683Gene Name
BUB1
Gene Alias
BUB1A, BUB1L, hBUB1
Gene Description
budding uninhibited by benzimidazoles 1 homolog (yeast)
Omim ID
602452Gene Ontology
HyperlinkGene Summary
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq
Other Designations
BUB1 budding uninhibited by benzimidazoles 1 homolog|budding uninhibited by benzimidazoles 1|mitotic spindle checkpoint kinase|putative serine/threonine-protein kinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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A dual role for Bub1 in the spindle checkpoint and chromosome congression.
Meraldi P, Sorger PK.
The EMBO Journal 2005 Apr; 24(8):1621.
Application:IF, WB, Human, HeLa cells.
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Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Tang Z, Shu H, Oncel D, Chen S, Yu H.
Molecular Cell 2004 Nov; 16(3):387.
Application:IP, WB, Human, HeLa cells.
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Mammalian BUB1 protein kinases: map positions and in vivo expression.
Pangilinan F, Li Q, Weaver T, Lewis BC, Dang CV, Spencer F.
Genomics 1997 Dec; 46(3):379.
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A dual role for Bub1 in the spindle checkpoint and chromosome congression.
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